RAS MAPK inhibitors deregulation in leukemia
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چکیده
منابع مشابه
RAS MAPK inhibitors deregulation in leukemia
The RAS (mitogen-activated protein kinase) MAPK pathway is commonly deregulated in human cancer, including childhood acute myeloid leukemias (AMLs). Canonical strong activating somatic mutation of RAS-MAPK pathway genes are recurrently found in AMLs. They affect integral components of the pathway, and upstream activators, and include NRAS, KRAS, BRAF, PTPN11, and FMS-related tyrosine kinase 3 (...
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Receptor Tyrosine Kinase (RTK)/Ras GTPase/MAP kinase (MAPK) signaling pathways are used repeatedly during metazoan development to control many different biological processes. In the nematode Caenorhabditis elegans, two different RTKs (LET-23/EGFR and EGL-15/FGFR) are known to stimulate LET-60/Ras and a MAPK cascade consisting of the kinases LIN-45/Raf, MEK-2/MEK and MPK-1/ERK. This Ras/MAPK cas...
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Deregulation of microRNAs' expression frequently occurs in acute myeloid leukemia (AML). Lower miR-181a expression is associated with worse outcomes, but the exact mechanisms by which miR-181a mediates this effect remain elusive. Aberrant activation of the RAS pathway contributes to myeloid leukemogenesis. Here, we report that miR-181a directly binds to 3'-untranslated regions (UTRs); downregul...
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ژورنال
عنوان ژورنال: Oncoscience
سال: 2015
ISSN: 2331-4737
DOI: 10.18632/oncoscience.274